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Abstract

AMP-activated protein kinase (AMPK) regulates energy homeostasis, which coordinates metabolic pathways which help in maintaining balance between nutrient supply and energy demand. It has also been considered a potential target for metabolic diseases and diabetic complications. The role of oxidative stress, mitochondrial dysfunction has been already been explored for their crucial role in the pathophysiology of diabetic complications including diabetic neuropathy. Hyperglycemia alters the DRG neurons and their mitochondria and causes down-regulation of AMPK expression, phosphorylation and activity. AMPK negatively regulates translation control pathways that increase DRG excitability, negative regulation of ion channel phosphorylation by MAPKs, likely targeting voltage gated sodium channels and by improving the quality (by inhibiting mitochondrial dysfunction) and quantity (by improving mitochondriogenesis). Also AMPK also impact positively against neuroinflammation by improving nrf2 activity. AMPK modulators have been shown to decrease the levels of neuronal IL-6, TNF-alpha and COX2 in addition to its effect of NF-kB signaling. These results reassure the protective effect of AMPK modulators by its effect on Oxidative stress-Mitochondrial Dysfunction-Neuroinflammation in experimental Diabetic complications.

Dr Ashutosh Kumar pracuje na Wydziale Farmakologii i Toksykologii Narodowego Instytutu Edukacji i Badań Farmaceutycznych (NIPER) w Hyderabadzie (Indie). Ukończył studia w Instytucie Nauk i Badań Farmaceutycznych w Delhi. Pracował dla międzynarodowych kampanii farmaceutycznych m.in. Novartis i Dr Reddys. Obiektem zainteresowań naukowych Dr A. Kumara jest patogeneza neuropatii cukrzycowej, neuropatii wywołanej chemioterapią, poszukiwanie substancji które zapobiegają tym schorzeniom oraz wyjaśnienie mechanizmów ich działania. Dr Ashutosh Kumar jest autorem ponad 49 publikacji naukowych oraz uczestnikiem wielu prestiżowych projektów naukowych m.in. z Uniwersytetem Manchester (UK).