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The Department of Animal Ecology is the home to two long term selection experiments.  

The first one consists of two unreplicated lines of mice divergently selected for rates of basal metabolism (BMR). This project has produced to date almost 50 generations of animals with a life-time stable ~50% difference in BMR. Throughout subsequent years of selection we looked for a number of physiological correlations, and were able to demonstrated that these animals differ significantly with respect to traits like organ and cell size, cell membrane composition, food intake, spontaneous activity, thermogenic capacity, reproductive effort or even adiposity later in life.

 
The second experiment is a selection for high aerobic capacity elicited by swimming in a 25°C water. We maintain four replicate selected lines along with four randomly bred control lines of animals. This selection is younger, however now approaching the 30th generation we have already reached a ~30% difference in VO2max between the selected and control lines. Since the selection protocol involves swimming in mild cold water, the selected and control lines also evolved some differences in thermogenic capacity. 

 

Publications from the H/L BMR selection experiment:

  • Sadowska J., Gębczyński A.K., Lewoc M., Konarzewski M. 2019. Not that hot after all: no limits to heat dissipation in lactating mice selected for high or low BMR. Journal of Experimental Biology,  jeb.204669 doi: 10.1242/jeb.204669
  • Sadowska J.,Gębczyński A.K., Konarzewski M. 2017.Metabolic risk factors in mice divergently selected for BMR fed high fat and high carb diets. PLoS ONE 12: e0172892. doi:10.1371/journal.pone.0172892
  • Książek A., Konarzewski M. 2016. Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR), Journal of Experimental Biology 219, 1542-1551, DOI: 10.1242/jeb.129312
  • Brzęk P., Gębczyński A.K., Książek A., Konarzewski M. 2016. Effect of calorie restriction on spontaneous physical activity and body mass in mice divergently selected for basal metabolic rate (BMR), Physiology & Behavior 161, 116-122, http://dx.doi.org/10.1016/j.physbeh.2016.04.022  
  • Sadowska J., Gębczyński A.K., Konarzewski M. 2015. Effect of reproduction on the consistency of the between-line type divergence in laboratory mice selected on basal metabolic rate. Physiological and Biochemical Zoology 88(3), DOI: 10.1086/680167.
  • Sadowska J., Gębczyński A.K., Paszko K., Konarzewski M. 2015. Milk output and composition in mice divergently selected for basal metabolic rate. The Journal of Experimental Biology 218: 249-254. 
  • Brzęk P., Książek A., Ołdakowski Ł., Konarzewski M. 2014. High basal metabolic rate does not elevate oxidative stress during reproduction in laboratory mice. Journal of Experimental Biology 217: 1504-1509. 
  • Maciak. S., Bonda-Ostaszewska E., Czarnołęski M., Konarzewski M., Kozłowski J. 2014. Mice divergently selected for high and low basal metabolic rates evolved different cell size and organ mass. Journal of Evolutionary Biology, doi: 10.1111/jeb.12306. 
  • Sadowska J., Gębczyński A. K, Konarzewski M. 2013. Basal metabolic rate is positively correlated with parental investment in laboratory mice. Proceedings of the Royal Society B, DOI: 10.1098/rspb.2012.2576. 
  • Brzęk P., Książek A., Dobrzyń A., Konarzewski M. 2012. Effect of dietary restriction on metabolic, anatomic and molecular traits in mice depends on the initial level of basal metabolic rate. Journal of Experimental Biology 215, 3191-3199.
  • Książek A., Konarzewski M. 2012. Effect of Dietary Restriction on Immune Response of Laboratory Mice Divergently Selected for Basal Metabolic Rate. Physiological and Biochemical Zoology 85(1): 51-61.
  • Gębczyński A.K., Konarzewski M. 2011. Effects of oxygen availability on maximum aerobic performance in Mus musculus selected for basal metabolic rate or aerobic capacity. The Journal of Experimental Biology 214: 1714-1720.
  • Gębczyński A.K., Konarzewski M. 2009. Locomotor activity of mice divergently selected for basal metabolic rate: a test of hypotheses on the evolution of endothermy. J. Evol. Biol. 22: 1212-1220.
  • Książek A., Czerniecki J., Konarzewski M. 2009. Phenotypic flexibility of traits related to energy acquisition in mice divergently selected for basal metabolic rate (BMR). Journal of Experimental Biology 212: 808-814.
  • Gębczyński A.K. 2008. Nonshivering thermogenesis capacity versus basal metabolic rate in laboratory mice. Journal of Thermal Biology 33: 250-254.
  • Brzęk P., Bielawska K., Książek A., Konarzewski M. 2007. Anatomic and molecular correlates of divergent selection for basal metabolic rate in laboratory mice. Physiological and Biochemical Zoology 80: 401-499.
  • Konarzewski M., Książek A., Łapo I. B. 2005. Artificial selection on metabolic rates and related traits in rodents. Integrative and Comparative Biology 45: 416-425.
  • Gębczyński A.K. 2005. Daily variation of thermoregulatory costs in laboratory mice selected for high and low basal metabolic rate. Journal of Thermal Biology 30: 187-193.
  • Książek A., Konarzewski M., Łapo I.B. 2004. Anatomic and Energetic Correlates of Divergent Selection for Basal Metabolic Rate in Laboratory Mice. Physiological and Biochemical Zoology 77(6): 890-899. 
  • Książek A., Konarzewski M., Chadzińska M., Cichoń M. 2003. Costs of immune response in cold-stressed laboratory mice selected for high and low basal metabolism rates. Proc. R. Soc. Lond. B 270: 2025-2031.

 

Publications from the VO2max selection experiment:

  • Sadowska J., Gębczyński A.K., Konarzewski M. 2018. Long-term trait  consistency in mice selected for swim-induced high aerobic capacity. Physiological and Biochemical Zoology, DOI: 10.1086/698213
  • Sadowska J., Gębczyński A.K., Konarzewski M. 2017. Selection for high aerobic capacity has no protective effect against obesity in laboratory mice. Physiology & Behavior 175C: 130-136, doi.org/10.1016/j.physbeh.2017.03.034
  • Gębczyński A.K., Konarzewski M. 2011. Effects of oxygen availability on maximum aerobic performance in Mus musculus selected for basal metabolic rate or aerobic capacity. The Journal of Experimental Biology 214: 1714-1720.
  • Gębczyński A.K., Konarzewski M. 2009. Metabolic correlates of selection on aerobic capacity in laboratory mice: a test of the model for the evolution of endothermy. J. Exp. Biol. 212: 2872-2878.
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